Acute myocardial infarction and heart failure are among the leading causes of death and disability in Singapore and worldwide. As such novel treatment strategies are required to protect the heart against the detrimental effects of acute ischaemia/reperfusion injury (IRI) and prevent the onset and progression of heart failure in order to preserve cardiac function and preventing the onset of heart failure. We use a translational approach to heart protection with the elucidation of underlying disease mechanisms and discovery of novel therapeutic targets using pre-clinical human IPSC, cells and animal disease models and investigate their therapeutic potential in proof-of-concept clinical studies and multi-centre clinical outcome randomised controlled trials.
Prof Derek Hausenloy
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